SPELL - Nematode

Citation	Roux AE, Yuan H, Podshivalova K, Hendrickson D, Kerr R, Kenyon C, Kelley D. Individual cell types in C. elegans age differently and activate distinct cell-protective responses. Cell Rep, 2023.
PubMed ID	37531250
Short Description	Individual cell types in C. elegans age differently and activate distinct cell-protective responses. GEO Record: GSE208154, Platform: GPL22765 Lab Atlas: http://c.elegans.aging.atlas.research.calicolabs.com/ Other resources: N.A.
# of Conditions	1
Full Description	Here we describe a single-cell atlas of aging for virtually every cell type of the nematode Caenorhabditis elegans. Our findings suggest that C. elegans aging is not random in nature, but rather characterized by coordinated changes in functionally related metabolic and stress-response genes in a highly cell-type specific fashion. Aging signatures of different cell types are largely different from one another, with downregulation of energy metabolism being the only nearly universal change. Similarly, the rates at which cells aged, measured as genome-wide expression changes, differed significantly between cell types. In some, but not all, cell types, aging was characterized by an increase in cell-to-cell variance. Finally, we identified a signature for longevity transcription factors (TFs) whose activities changed coordinately across many cell types with age. We discovered new candidates, such as GEI-3, among these TFs that likely also regulate the aging rate. Our dataset can be accessed and queried at c.elegans.aging.atlas.research.calicolabs.com/.
Tags	Method: Single-Cell RNA-Seq, Species: Caenorhabditis elegans, Topic: aging