| Citation | Hassan WM, Dostal V, Huemann BN, Yerg JE, Link CD. Identifying A-specific pathogenic mechanisms using a nematode model of Alzheimer's disease. Neurobiol Aging, 2015. |
| PubMed ID | 25457027 |
| Short Description | Identifying A-specific pathogenic mechanisms using a nematode model of Alzheimer's disease. GEO Record: GSE65851 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00046102.ce.mr.csv |
| # of Conditions | 47 |
Full Description
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Multiple gene expression alterations have been linked to Alzheimer's disease (AD), implicating multiple metabolic pathways in its pathogenesis. However, a clear distinction between AD-specific gene expression changes and those resulting from nonspecific responses to toxic aggregating proteins has not been made. We investigated alterations in gene expression induced by human beta-amyloid peptide (A) in a Caenorhabditis elegans AD model. A-induced gene expression alterations were compared with those caused by a synthetic aggregating protein to identify A-specific effects. Both A-specific and nonspecific alterations were observed. Among A-specific genes were those involved in aging, proteasome function, and mitochondrial function. An intriguing observation was the significant overlap between gene expression changes induced by A and those induced by Cry5B, a bacterial pore-forming toxin. This led us to hypothesize that A exerts its toxic effect, at least in part, by causing damage to biological membranes. We provide in vivo evidence consistent with this hypothesis. This study distinguishes between A-specific and nonspecific mechanisms and provides potential targets for therapeutics discovery. Experimental Details: WBPaper00046102:GFP_0hr_rep1 WBPaper00046102:GFP_4hr_rep1 WBPaper00046102:GFP_8hr_rep1 WBPaper00046102:GFP_8hr_rep2 WBPaper00046102:GFP_8hr_rep3 WBPaper00046102:GFP_8hr_rep4 WBPaper00046102:GFP_12hr_rep1 WBPaper00046102:GFP_12hr_rep2 WBPaper00046102:GFP_12hr_rep3 WBPaper00046102:GFP_12hr_rep4 WBPaper00046102:GFP_12hr_rep5 WBPaper00046102:GFP_16hr_rep1 WBPaper00046102:GFP_16hr_rep2 WBPaper00046102:GFP_16hr_rep3 WBPaper00046102:GFP_16hr_rep4 WBPaper00046102:GFP_20hr_rep1 WBPaper00046102:GFP-degron_0hr_rep1 WBPaper00046102:GFP-degron_4hr_rep1 WBPaper00046102:GFP-degron_8hr_rep1 WBPaper00046102:GFP-degron_8hr_rep2 WBPaper00046102:GFP-degron_8hr_rep3 WBPaper00046102:GFP-degron_8hr_rep4 WBPaper00046102:GFP-degron_12hr_rep1 WBPaper00046102:GFP-degron_12hr_rep2 WBPaper00046102:GFP-degron_12hr_rep3 WBPaper00046102:GFP-degron_12hr_rep4 WBPaper00046102:GFP-degron_12hr_rep5 WBPaper00046102:GFP-degron_16hr_rep1 WBPaper00046102:GFP-degron_16hr_rep2 WBPaper00046102:GFP-degron_16hr_rep3 WBPaper00046102:GFP-degron_16hr_rep4 WBPaper00046102:GFP-degron_20hr_rep1 WBPaper00046102:Abeta_0hr_rep1 WBPaper00046102:Abeta_4hr_rep1 WBPaper00046102:Abeta_8hr_rep1 WBPaper00046102:Abeta_8hr_rep2 WBPaper00046102:Abeta_8hr_rep3 WBPaper00046102:Abeta_8hr_rep4 WBPaper00046102:Abeta_12hr_rep1 WBPaper00046102:Abeta_12hr_rep2 WBPaper00046102:Abeta_12hr_rep3 WBPaper00046102:Abeta_12hr_rep4 WBPaper00046102:Abeta_16hr_rep1 WBPaper00046102:Abeta_16hr_rep2 WBPaper00046102:Abeta_16hr_rep3 WBPaper00046102:Abeta_16hr_rep4 WBPaper00046102:Abeta_20hr_rep1. |
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