| Citation | Martorell P, Llopis S, Gonzalez N, Chenoll E, Lopez-Carreras N, Aleixandre A, Chen Y, Karoly ED, Ramon D, Genoves S. The Probiotic Strain Bifidobacterium animalis subsp. lactis CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in Caenorhabditis elegans. J Agric Food Chem, 2016. |
| PubMed ID | 27054371 |
| Short Description | The Probiotic Strain Bifidobacterium animalis subsp. lactis CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in Caenorhabditis elegans. GEO Record: GSE63531 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00049417.ce.mr.csv |
| # of Conditions | 8 |
Full Description
|
Recently, microbial changes in the human gut have been proposed as a possible cause of obesity. Therefore, modulation of microbiota through probiotic supplements is of great interest to support obesity therapeutics. The present study examines the functional effect and metabolic targets of a bacterial strain, Bifidobacterium animalis subsp. lactis CECT 8145, selected from a screening in Caenorhabditis elegans. This strain significantly reduced total lipids (40.5% +/- 2.4) and triglycerides (TG) (27.6%+/-0.5), exerting antioxidant effects in the nematode (30% +/- 2.8 increase in survival vs. control); activities also preserved in a final food matrix (milk). Furthermore, transcriptomic and metabolomic analyses in nematodes fed with strain CECT 8145 revealed modulation of the energy and lipid metabolism, as well as the tryptophan metabolism (satiety) as the main metabolic targets of the probiotic. In conclusion, our study describes for the first time a new B. animalis subsp. lactis strain, CECT 8145, as a promising probiotic for obesity disorders. Furthermore, data supports future studies in obesity murine model. Experimental Details: WBPaper00049417:NGM_SL112 WBPaper00049417:NGM_SL114 WBPaper00049417:NGM_SL116 WBPaper00049417:NGM_SL118 WBPaper00049417:B.animalis_SL113 WBPaper00049417:B.animalis_SL115 WBPaper00049417:B.animalis_SL117 WBPaper00049417:B.animalis_SL119. |
|
Tags
|
Contact: help (at) wormbase.org
