| Citation | Herholz M, Cepeda E, Baumann L, Kukat A, Hermeling J, Maciej S, Szczepanowska K, Pavlenko V, Frommolt P, Trifunovic A. KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants. Nat Commun, 2019. |
| PubMed ID | 31346165 |
| Short Description | KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants. GEO Record: GSE61771 Platform: GPL19230 Download gene-centric, log2 transformed data: WBPaper00059194.ce.mr.csv |
| # of Conditions | 12 |
Full Description
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Most manipulations that extend lifespan also increase resistance to various stress factors and environmental cues in a range of animals from yeast to mammals. However, the underlying molecular mechanisms regulating stress resistance during aging are still largely unknown. Here we identify Kruppel-like factor 1 (KLF-1) as a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function. A redox-regulated KLF-1 activation and transfer to the nucleus coincides with the peak of somatic mitochondrial biogenesis that occurs around a transition from larval stage L3 to D1. We further show that KLF-1 activates genes involved in the xenobiotic detoxification programme and identified cytochrome P450 oxidases, the KLF-1 main effectors, as longevity-assurance factors of mitochondrial mutants. Collectively, these findings underline the importance of the xenobiotic detoxification in the mitohormetic, longevity assurance pathway and identify KLF-1 as a central factor in orchestrating this response. Experimental Details: WBPaper00059194:isp-1(qm150);ctb-1(qm189)_klf-1(RNAi)-post-L4_rep1 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_klf-1(RNAi)-post-L4_rep2 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_klf-1(RNAi)-post-L4_rep3 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_klf-1(RNAi)-pre-L4_rep1 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_klf-1(RNAi)-pre-L4_rep2 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_klf-1(RNAi)-pre-L4_rep3 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_control_rep1 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_control_rep2 WBPaper00059194:isp-1(qm150);ctb-1(qm189)_control_rep3 WBPaper00059194:N2_control_rep1 WBPaper00059194:N2_control_rep2 WBPaper00059194:N2_control_rep3. |
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