| Citation | Nono M, Kishimoto S, Sato-Carlton A, Carlton PM, Nishida E, Uno M. Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C.elegans. Cell Rep, 2020. |
| PubMed ID | 32160530 |
| Short Description | Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C.elegans. GEO Record: GSE119917 Platform: GPL19230 Download gene-centric, log2 transformed data: WBPaper00059406.ce.mr.csv |
| # of Conditions | 8 |
Full Description
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Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance remain largely unknown. Here, we identify the intestine-to-germline communication of epigenetic states, which intergenerationally enhances stress resistance in C.elegans. The alterations in epigenetic states by deficiency of the histone H3K4me3 modifier ASH-2 in the intestine or germline increase organismal stress resistance, which is abrogated by knockdown of the H3K4 demethylase RBR-2. Remarkably, the increase in stress resistance induced by ASH-2 deficiency in the intestine is abrogated by RBR-2 knockdown in the germline, suggesting the intestine-to-germline transmission of epigenetic information. This communication from intestine to germline in the parental generation increases stress resistance in the next generation. Moreover, the intertissue communication is mediated partly by transcriptional regulation of F08F1.3. These results reveal that intertissue communication of epigenetic information provides mechanisms forintergenerational regulation of systemic stress resistance. Experimental Details: WBPaper00059406:N2_control WBPaper00059406:N2_ash-2(RNAi) WBPaper00059406:VP303_control WBPaper00059406:VP303_ash-2(RNAi) WBPaper00059406:NR350_control WBPaper00059406:NR350_ash-2(RNAi) WBPaper00059406:TU3401_control WBPaper00059406:TU3401_ash-2(RNAi). |
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