SPELL - Nematode

Citation	Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, Schiavi A, Steinwachs S, Esser C, Menzel R, Giani Tagliabue S, Bonati L, Cox F, Ale-Agha N, Jakobs P, Altschmied J, Haendeler J, Coumoul X, Ventura N. Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects. Antioxidants (Basel), 2022.
PubMed ID	35453298
Short Description	Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects. GEO Record: GSE195769 Platform: GPL19230 Download gene-centric, log2 transformed data: WBPaper00064073.ce.mr.csv
# of Conditions	20
Full Description	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how the AhR mediates the anti-aging effects of curcumin across species. Using a combination of in vivo, in vitro, and in silico analyses, we demonstrated that curcumin has AhR-dependent or -independent effects in a context-specific manner. We found that in Caenorhabditis elegans, AhR mediates curcumin-induced lifespan extension, most likely through a ligand-independent inhibitory mechanism related to its antioxidant activity. Curcumin also showed AhR-independent anti-aging activities, such as protection against aggregation-prone proteins and oxidative stress in C. elegans and promotion of the migratory capacity of human primary endothelial cells. These AhR-independent effects are largely mediated by the Nrf2/SKN-1 pathway. Experimental Details: WBPaper00064073:N2_DMSO_rep1 WBPaper00064073:N2_DMSO_rep2 WBPaper00064073:N2_DMSO_rep3 WBPaper00064073:N2_DMSO_rep4 WBPaper00064073:N2_DMSO_rep5 WBPaper00064073:N2_curcumin_rep1 WBPaper00064073:N2_curcumin_rep2 WBPaper00064073:N2_curcumin_rep3 WBPaper00064073:N2_curcumin_rep4 WBPaper00064073:N2_curcumin_rep5 WBPaper00064073:ahr-1(ju145)_DMSO_rep1 WBPaper00064073:ahr-1(ju145)_DMSO_rep2 WBPaper00064073:ahr-1(ju145)_DMSO_rep3 WBPaper00064073:ahr-1(ju145)_DMSO_rep4 WBPaper00064073:ahr-1(ju145)_DMSO_rep5 WBPaper00064073:ahr-1(ju145)_curcumin_rep1 WBPaper00064073:ahr-1(ju145)_curcumin_rep2 WBPaper00064073:ahr-1(ju145)_curcumin_rep3 WBPaper00064073:ahr-1(ju145)_curcumin_rep4 WBPaper00064073:ahr-1(ju145)_curcumin_rep5.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: response to chemical, Topic: WT vs. mutant