SPELL - Nematode

Citation	Rockman MV, Skrovanek SS, KRUGLYAK L. Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science, 2010.
PubMed ID	20947766
Short Description	Selection at linked sites shapes heritable phenotypic variation in C. elegans. GEO Record: GSE23857 Platform: GPL7727 Download gene-centric, log2 transformed data: WBPaper00037680.ce.mr.csv
# of Conditions	208
Full Description	Mutation generates the heritable variation that genetic drift and natural selection shape. In classical quantitative genetic models, drift is a function of the effective population size and acts uniformly across traits, whereas mutation and selection act trait-specifically. We identified thousands of quantitative trait loci (QTLs) influencing transcript abundance traits in a cross of two Caenorhabditis elegans strains; although trait-specific mutation and selection explained some of the observed pattern of QTL distribution, the pattern was better explained by trait-independent variation in the intensity of selection on linked sites. Our results suggest that traits in C. elegans exhibit different levels of variation less because of their own attributes than because of differences in the effective population sizes of the genomic regions harboring their underlying loci. Experimental Details: WBPaper00037680:Strain_QX1_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX194_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX195_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX197_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX199_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX200_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX202_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX203_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX204_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX209_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX20_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX21_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX212_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX213_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX216_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX217_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX220_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX222_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX223_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX224_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX226_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX227_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX228_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX233_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX235_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX25_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX26_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX28_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX29_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX30_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX31_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX32_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX33_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX37_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX3_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX41_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX44_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX45_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX47_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX48_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX51_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX52_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX53_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX56_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX4_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX58_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX60_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX64_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX65_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX66_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX67_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX68_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX69_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX70_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX72_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX74_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX6_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX81_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX82_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX83_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX85_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX86_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX87_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX88_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX90_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX91_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX93_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX94_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX98_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX103_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX107_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX108_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX111_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX113_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX115_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX11_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX119_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX120_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX121_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX128_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX132_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX134_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX13_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX135_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX136_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX140_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX141_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX142_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX144_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX145_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX148_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX150_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX151_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX154_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX15_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX158_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX159_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX161_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX162_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX164_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX165_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX166_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX167_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX168_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX169_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX170_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX172_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX174_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX16_Cy5_vs_CommonReference_Cy3 WBPaper00037680:Strain_QX19_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX196_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX198_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX205_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX206_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX207_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX208_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX210_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX211_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX214_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX215_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX218_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX221_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX22_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX225_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX229_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX230_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX231_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX232_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX234_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX236_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX24_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX237_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX27_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX34_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX38_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX2_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX39_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX40_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX42_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX43_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX49_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX54_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX55_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX5_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX59_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX61_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX62_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX63_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX71_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX73_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX76_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX77_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX7_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX78_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX79_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX80_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX84_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX92_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX95_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX8_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX9_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX96_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX97_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX99_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX100_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX101_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX102_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX104_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX106_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX109_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX112_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX114_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX10_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX117_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX124_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX125_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX127_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX129_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX131_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX133_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX12_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX137_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX138_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX139_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX143_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX147_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX149_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX153_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX14_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX156_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX157_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX160_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX163_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX171_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX173_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX177_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX178_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX179_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX180_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX181_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX182_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX183_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX184_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX185_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX187_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX189_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX192_Cy3_vs_CommonReference_Cy5 WBPaper00037680:Strain_QX193_Cy3_vs_CommonReference_Cy5.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: unclassified