| Citation | Noble LM, Chang AS, McNelis D, Kramer M, Yen M, Nicodemus JP, Riccardi DD, Ammerman P, Phillips M, Islam T, Rockman MV. Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C.elegans. Curr Biol, 2015. |
| PubMed ID | 26455306 |
| Short Description | Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C.elegans. GEO Record: GSE68351 Platform: GPL10094 Download gene-centric, log2 transformed data: WBPaper00048657.ce.mr.csv |
| # of Conditions | 24 |
Full Description
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In sexual species, gametes have to find and recognize one another. Signaling is thus central to sexual reproduction and involves a rapidly evolving interplay of shared and divergent interests [1-4]. Among Caenorhabditis nematodes, three species have evolved self-fertilization, changing the balance of intersexual relations [5]. Males in these androdioecious species are rare, and the evolutionary interests of hermaphrodites dominate. Signaling has shifted accordingly, with females losing behavioral responses to males [6, 7] and males losing competitive abilities [8, 9]. Males in these species also show variable same-sex and autocopulatory mating behaviors [6, 10]. These behaviors could have evolved by relaxed selection on male function, accumulation of sexually antagonistic alleles that benefit hermaphrodites and harm males [5, 11], or neither of these, because androdioecy also reduces the ability of populations to respond to selection [12-14]. We have identified the genetic cause of a male-male mating behavior exhibited by geographically dispersed C.elegans isolates, wherein males mate with and deposit copulatory plugs on one another's excretory pores. We find a single locus of major effect that is explained by segregation of a loss-of-function mutation in an uncharacterized gene, plep-1, expressed in the excretory cell in both sexes. Males homozygous for the plep-1 mutation have excretory pores that are attractive or receptive to copulatory behavior of other males. Excretory pore plugs are injurious and hermaphrodite activity is compromised in plep-1 mutants, so the allele might be unconditionally deleterious, persisting in the population because the species' androdioecious mating system limits the reach of selection. Experimental Details: WBPaper00048657:N2_vs_reference_rep1-hyb1 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep1-hyb1 WBPaper00048657:N2_vs_reference_rep2-hyb1 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep2-hyb1 WBPaper00048657:N2_vs_reference_rep3-hyb1 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep3-hyb1 WBPaper00048657:N2_vs_reference_rep4-hyb1 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep4-hyb1 WBPaper00048657:N2_vs_reference_rep1-hyb2 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep1-hyb2 WBPaper00048657:N2_vs_reference_rep2-hyb2 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep2-hyb2 WBPaper00048657:N2_vs_reference_rep3-hyb2 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep3-hyb2 WBPaper00048657:N2_vs_reference_rep4-hyb2 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep4-hyb2 WBPaper00048657:N2_vs_reference_rep1-hyb3 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep1-hyb3 WBPaper00048657:N2_vs_reference_rep2-hyb3 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep2-hyb3 WBPaper00048657:N2_vs_reference_rep3-hyb3 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep3-hyb3 WBPaper00048657:N2_vs_reference_rep4-hyb3 WBPaper00048657:plep-1(ttTi53821)_vs_reference_rep4-hyb3. |
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