| Citation | Turek M, Besseling J, Spies JP, Konig S, Bringmann H. Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep. Elife, 2016. |
| PubMed ID | 26949257 |
| Short Description | Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep. GEO Record: GSE73282 GSE73283 Platform: GPL11346 Download gene-centric, log2 transformed data: WBPaper00049336.ce.mr.csv |
| # of Conditions | 16 |
Full Description
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Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that express GABA. However, little is known about how sleep neuron function is determined and how sleep neurons change physiology and behavior systemically. Here, we investigated sleep in C. elegans, which is induced by the single sleep-active neuron RIS. We found that the transcription factor LIM-6, which specifies GABAergic function, in parallel determines sleep neuron function through the expression of APTF-1, which specifies the expression of FLP-11 neuropeptides. Surprisingly FLP-11, and not GABA, is the major component that determines the sleep-promoting function of RIS. FLP-11 is constantly expressed in RIS. At sleep onset RIS depolarizes and releases FLP-11 to induce a systemic sleep state. Experimental Details: WBPaper00049336:aptf-1(gk794)_L4_rep1 WBPaper00049336:aptf-1(gk794)_L4_rep2 WBPaper00049336:aptf-1(gk794)_L4_rep3 WBPaper00049336:aptf-1(gk794)_L4_rep4 WBPaper00049336:N2_L4_rep1 WBPaper00049336:N2_L4_rep2 WBPaper00049336:N2_L4_rep3 WBPaper00049336:N2_L4_rep4 WBPaper00049336:aptf-1(gk794)_3-fold-embryo_rep1 WBPaper00049336:aptf-1(gk794)_3-fold-embryo_rep2 WBPaper00049336:aptf-1(gk794)_3-fold-embryo_rep3 WBPaper00049336:aptf-1(gk794)_3-fold-embryo_rep4 WBPaper00049336:N2_3-fold-embryo_rep1 WBPaper00049336:N2_3-fold-embryo_rep2 WBPaper00049336:N2_3-fold-embryo_rep3 WBPaper00049336:N2_3-fold-embryo_rep4. |
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