SPELL - Nematode

Citation	Hunt VL, Tsai IJ, Coghlan A, Reid AJ, Holroyd N, Foth BJ, Tracey A, Cotton JA, Stanley EJ, Beasley H, Bennett HM, Brooks K, Harsha B, Kajitani R, Kulkarni A, Harbecke D, Nagayasu E, Nichol S, Ogura Y, Quail MA, Randle N, Xia D, Brattig NW, Soblik H, Ribeiro DM, Sanchez-Flores A, Hayashi T, Itoh T, Denver DR, Grant W, Stoltzfus JD, Lok JB, Murayama H, Wastling J, Streit A, Kikuchi T, Viney M, Berriman M. The genomic basis of parasitism in the Strongyloides clade of nematodes. Nat Genet, 2016.
PubMed ID	26829753
Short Description	The genomic basis of parasitism in the Strongyloides clade of nematodes. GEO Record: N.A. Platform: N.A. Download gene-centric, log2 transformed data: WBPaper00050919.ce.ms.csv
# of Conditions	12
Full Description	Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families--families encoding astacin-like and SCP/TAPS proteins--is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism. Experimental Details: MassSpec_WBPaper00050919:S.ratti_FreeLiving_rep1_01 MassSpec_WBPaper00050919:S.ratti_FreeLiving_rep1_02 MassSpec_WBPaper00050919:S.ratti_FreeLiving_rep1_03 MassSpec_WBPaper00050919:S.ratti_FreeLiving_rep2_01 MassSpec_WBPaper00050919:S.ratti_FreeLiving_rep2_02 MassSpec_WBPaper00050919:S.ratti_FreeLiving_rep2_03 MassSpec_WBPaper00050919:S.ratti_Parasitic_rep1_01 MassSpec_WBPaper00050919:S.ratti_Parasitic_rep1_02 MassSpec_WBPaper00050919:S.ratti_Parasitic_rep1_03 MassSpec_WBPaper00050919:S.ratti_Parasitic_rep2_01 MassSpec_WBPaper00050919:S.ratti_Parasitic_rep2_02 MassSpec_WBPaper00050919:S.ratti_Parasitic_rep2_03.
Tags	Method: proteomics, Species: Caenorhabditis elegans, Topic: gene expression - general