| Citation | Schmeisser K, Kaptan D, Raghuraman BK, Shevchenko A, Rodenfels J, Penkov S, Kurzchalia TV. Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling. Commun Biol, 2024. |
| PubMed ID | 38267699 |
| Short Description | Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling. GEO Record: N.A. Platform: N.A. Download gene-centric, log2 transformed data: WBPaper00066417.ce.ms.csv |
| # of Conditions | 12 |
Full Description
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Recovery from the quiescent developmental stage called dauer is an essential process in C. elegans and provides an excellent model to understand how metabolic transitions contribute to developmental plasticity. Here we show that cholesterol bound to the small secreted proteins SCL-12 or SCL-13 is sequestered in the gut lumen during the dauer state. Upon recovery from dauer, bound cholesterol undergoes endocytosis into lysosomes of intestinal cells, where SCL-12 and SCL-13 are degraded and cholesterol is released. Free cholesterol activates mTORC1 and is used for the production of dafachronic acids. This leads to promotion of protein synthesis and growth, and a metabolic switch at the transcriptional level. Thus, mobilization of sequestered cholesterol stores is the key event for transition from quiescence to growth, and cholesterol is the major signaling molecule in this process. Experimental Details: MassSpec_WBPaper00066417:Dauer_BR1_Rep1 MassSpec_WBPaper00066417:Dauer_BR1_Rep2 MassSpec_WBPaper00066417:Dauer_BR2_Rep1 MassSpec_WBPaper00066417:Dauer_BR2_Rep2 MassSpec_WBPaper00066417:Dauer_BR3_Rep1 MassSpec_WBPaper00066417:Dauer_BR3_Rep2 MassSpec_WBPaper00066417:L3_BR1_Rep1 MassSpec_WBPaper00066417:L3_BR1_Rep2 MassSpec_WBPaper00066417:L3_BR2_Rep1 MassSpec_WBPaper00066417:L3_BR2_Rep2 MassSpec_WBPaper00066417:L3_BR3_Rep1 MassSpec_WBPaper00066417:L3_BR3_Rep2. |
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