SPELL - Nematode

Citation	Welker NC, Habig JW, Bass BL. Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. RNA, 2007.
PubMed ID	17526642
Short Description	Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. GEO Record: N.A. Platform: N.A. Download gene-centric, log2 transformed data: WBPaper00029437.ce.mr.csv
# of Conditions	5
Full Description	We describe the first microarray analysis of a whole animal containing a mutation in the Dicer gene. We used adult Caenorhabditis elegans and, to distinguish among different roles of Dicer, we also performed microarray analyses of animals with mutations in rde-4 and rde-1, which are involved in silencing by siRNA, but not miRNA. Surprisingly, we find that the X chromosome is greatly enriched for genes regulated by Dicer. Comparison of all three microarray data sets indicates the majority of Dicer-regulated genes are not dependent on RDE-4 or RDE-1, including the X-linked genes. However, all three data sets are enriched in genes important for innate immunity and, specifically, show increased expression of innate immunity genes. Experimental Details: WBPaper00029437:dcr-1_unc-32 WBPaper00029437:N2 WBPaper00029437:rde-1 WBPaper00029437:rde-4 WBPaper00029437:unc-32.
Tags	Method: microarray, Species: Caenorhabditis elegans, Topic: innate immune response