| Citation | Bolz DD, Tenor JL, Aballay A. A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J Biol Chem, 2010. |
| PubMed ID | 20133945 |
| Short Description | A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. GEO Record: GSE20053 Platform: GPL200 Download gene-centric, log2 transformed data: WBPaper00035892.ce.mr.csv |
| # of Conditions | 6 |
Full Description
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Yersinia pestis has acquired a variety of complex strategies that enable the bacterium to overcome defenses in different hosts and ensure its survival and successful transmission. A full-genome microarray analysis on Caenorhabditis elegans infected with Y. pestis shows enrichment in genes that are markers of innate immune responses and regulated by a conserved PMK-1/p38 MAPK. Consistent with a role in regulating expression of immune effectors, inhibition of PMK-1/p38 by mutation or RNA interference enhances susceptibility to Y. pestis. Further studies of mosaic animals where PMK-1/p38 is exclusively inhibited or overexpressed in a tissue-specific manner indicate that PMK-1/p38 controls expression of a CUB-like family of immune genes at the cell-autonomous level. Given the conserved nature of PMK-1/p38 MAPK-mediated signaling and innate immune responses, PMK-1/p38 MAPK may play a role in the immune response against Y. pestis in natural hosts. Experimental Details: WBPaper00035892:N2_KIM5_24h_A WBPaper00035892:N2_KIM5_24h_B WBPaper00035892:N2_KIM5_24h_C WBPaper00035892:N2_OP50_24h_A WBPaper00035892:N2_OP50_24h_B WBPaper00035892:N2_OP50_24h_C. |
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